Serological Classification of C. Diphtheriae in Calcutta
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Serological Classification of C. Diphtheriæ in Calcutta
Classification of C. diphtherice into gravis, mitis and intermedins groups according to their cultural and other biological character is well known (Anderson et al. 1931). A perusal of literature shows that serological classification of C. diphtheria?, though known since 1896 has been placed on a sound footing only recently by Hewitt (1947a) in England and Ferris (1950) in Australia after a tho...
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Between the years 1932 and 1935 there were frequent outbreaks of meningitis in an epidemic form in Calcutta and disappointing results were obtained with serum therapy in Calcutta hospitals. The same disappointing results were also reported from the United States of America. Sara Branham of the National Institute of Health, United States Public Health Service, Washington, D. C., took up the stud...
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Background and Objective: In Indonesia, diphtheria cases caused by Corynebacterium diphtheriae are still occurring until today. One of the causes is probably the diphtheria toxin repressor (dtxR) gene which influences toxin expression. Therefore, in this study the characterization of the gene was performed to determine the mutations that affect the DtxR protein. Methods: The dtxR genes of ...
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The conversion to toxigenicity of nontoxigenic Corynebacterium diphtheriae strain C4 requires the active and continued participation of a specific bacteriophage (Groman, 1953, 1955). The facts supporting this statement are: (1) lysogenization with 3 phage results in a simultaneous change to toxigenicity, and (2) reversion of toxngemnc cells to the nonlysogenic state results in a return to the n...
متن کاملDiphtheria bacteriophages and their relation to the development of bacterial variants.
Many strains of Corynebacterium diphtheriae carry phages capable of lysing other strains. Diphtheria phages are type-specific and do not lyse strains which are serologically unrelated but susceptibility to a phage may vary among different members of the same serological type and this can be used to differentiate subtypes of different biological behaviour. Phage-resistant mutants are readily sel...
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